发明名称 |
COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF |
摘要 |
The invention provides compositions, including pharmaceutical preparations, which comprise one or more substituted thiophene, benzofuran, pyrimidinetrione, dihydropyridine, tetrahydrocarbazol or anthraquinone compounds. The invention also features methods of use of such compositions in increasing activity of mutant-cystic fibrosis transmembrane conductance regulator protein in a cell, e.g., by increasing ion transport in a mutant-CFTR. |
申请公布号 |
WO2004110352(A2) |
申请公布日期 |
2004.12.23 |
申请号 |
WO2004US15386 |
申请日期 |
2004.05.14 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;VERKMAN, ALAN;GALIETTA, LUIS J.V.;GUY, R. KIPLIN |
发明人 |
VERKMAN, ALAN;GALIETTA, LUIS J.V.;GUY, R. KIPLIN |
分类号 |
A61K;A61K31/12;A61K31/36;A61K31/38;A61K31/40;A61K31/44;A61K31/505 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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