发明名称 |
Methods of using multivalent MHC class II-peptide chimeras |
摘要 |
The present invention provides a multimeric complex of at least two chimeric molecules, wherein the chimeric molecules comprise an immunoglobulin constant region element and two MHC elements wherein each MHC element is associated with a peptide, and wherein the chimeric molecules are covalently linked through a carbohydrate residue of the immunoglobulin constant region element by a polyalkylene glycol linker. Methods of making and using the multimeric complexes are also provided.
|
申请公布号 |
US2004258697(A1) |
申请公布日期 |
2004.12.23 |
申请号 |
US20040785705 |
申请日期 |
2004.02.24 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY |
发明人 |
BRUMEANU TEODOR DORU;CASARES SOFIA;BONA CONSTANTIN A. |
分类号 |
A61K39/385;A61K39/395;C07K14/31;C07K14/315;C07K14/74;C07K16/46;G01N33/50;G01N33/564;G01N33/569;(IPC1-7):A61K39/395 |
主分类号 |
A61K39/385 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|