发明名称 |
METHODS FOR IDENTIFYING COMPOUNDS THAT AFFECT RNA/RNA BINDING PROTEIN INTERACTIONS |
摘要 |
Disclosed herein are nucleic acid sequences and their optimized subfragments which are located in the mRNA untranslated regions of therapeutically-relevant genes. These sequences specifically bind RNA binding proteins (RBPs) and/or regulate the mRNA functionality. Also disclosed are methods of optimizing a subfragment of a parent nucleic acid sequence such that the RBP binding activity or mRNA functionality of the parent nucleic acid sequence is preserved in the optimized subfragment. |
申请公布号 |
EP1235840(A4) |
申请公布日期 |
2004.12.22 |
申请号 |
EP20000977133 |
申请日期 |
2000.11.09 |
申请人 |
MESSAGE PHARMACEUTICALS, INC. |
发明人 |
GIORDANO, ANTHONY;XAVIER, ASISH, K. |
分类号 |
C07H21/02;C07H21/04;C12N9/22;C12P19/34;C12P21/04;C12Q1/00;C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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