PROCESS FOR ASYMMETRIC INTRAMOLECULAR (3+2) CYCLO-ADDITION OF HYDRAZONES

摘要

An intramolecular Ä3+2Ü cycloaddition reaction of a hydrazone is carried out under a mild condition with a high stereoselectivity and yield by reacting a hydrazone derivative in the presence of an asymmetric catalyst system obtained by mixing a zirconium alkoxide represented by the following formula (I): Zr(OR)4 (wherein R is a hydrocarbon group which may have a substituent) with a binaphthol derivative represented by the following formula (II): (wherein Y<1> and Y<2> are each identical or different and denote a hydrogen atom or a halogen atom, and at least one of Y<1> and Y<2> denotes a halogen atom).