发明名称 |
CORE-SHELL TYPE PARTICLES HAVING SIGNAL-GENERATING SUBSTANCE ENCLOSED THEREIN AND PROCESS FOR PRODUCING THE SAME |
摘要 |
<p>A core-shell particle including a signal-generating substance therein, wherein the core-shell particle consists of (1) a core portion substantially made of a water-insoluble polymer compound; and (2) a shell portion substantially made of a water-soluble polymer compound having a reactive functional group, and covering a surface of the core portion in the manner of bristles of a brush; and the core portion and the shell portion are, as a whole, a block copolymer of a water-insoluble polymer and a water-soluble polymer, characterized in that the signal-generating substance is included in the core portion, is disclosed, and a process for producing the same is also disclosed. The core-shell particle including a signal-generating substance therein is useful as a labeling substance in which neither radioisotopes having handling restrictions nor unstable enzymes are required, a high sensitivity superior to fluorescent substances is achieved, and nonspecific absorption does not occur.</p> |
申请公布号 |
EP1398635(A4) |
申请公布日期 |
2004.12.22 |
申请号 |
EP20020730783 |
申请日期 |
2002.05.30 |
申请人 |
MITSUBISHI KAGAKU IATRON, INC.;NANOCARRIER CO., LTD. |
发明人 |
KATAOKA, KAZUNORI;NAGASAKI, YUKIO;SHIBATA, NAOYA;HOSHINO, NOBUHIRO |
分类号 |
G01N33/58;(IPC1-7):G01N33/533;G01N33/545 |
主分类号 |
G01N33/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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