| 发明名称 |
FORME ACTIVE D'UNE PROTEINE HEDGEHOG, PROCEDE POUR LA PRODUIRE, ET SON UTILISATION THERAPEUTIQUE |
| 摘要 |
The present invention provides isolated highly active hedgehog proteins esterified with a fatty acid having from 14 to 20 carbon atoms at the N-terminal domain of the protein. The highly active hh proteins are particularly useful therapeutic agents for treating bone disorders and neurodegenerative diseases. Methods for obtaining the highly active modified hedgehog proteins are also provided. |
| 申请公布号 |
MA26570(A1) |
申请公布日期 |
2004.12.20 |
| 申请号 |
MA19980025362 |
申请日期 |
1998.11.27 |
| 申请人 |
BOEHRINGER MANNHEIM GMBH |
发明人 |
ULRIKE LESER;KURT LANG;TILMAN SEYTTER |
| 分类号 |
C12N15/09;A61K38/00;A61P19/04;A61P19/08;A61P25/00;C07K14/46;C07K14/47;C12N15/12;C12P21/02;(IPC1-7):C12N15/12;C12N15/86;C12N5/10;A61K38/17 |
主分类号 |
C12N15/09 |
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