New peptide from the phosphatase CDC25B, useful for treatment of cancer and for drug screening, contains a phosphorylated serine redisue, also specific antibodies for treatment, diagnosis and prognosis

摘要

Peptide (A) that comprises, or consists of, at least 10 amino acids (aa) from the sequence (S1), is new. Peptide (A) that comprises, or consists of, at least 10 amino acids (aa) from the sequence is new. Serp is phosphorylated serine and (A) must include Serp. Independent claims are also included for the following: (1) poly- or mono-clonal antibodies (Ab) that recognize (A); (2) producing Ab; (3) pharmaceutical composition that contains (A) or Ab; (4) in vitro diagnosis or prognosis of cancer (particularly of the breast) in humans and animals comprising using Ab to detect (A); and (5) screening for compounds (X) able to bind to (A). Thr-Pro-Val-Gln-Asn-Lys-(Arg)3-Serp-Val-Thr-Pro-Pro-Glu-Glu-Gln-Gln-Glu (S1) ACTIVITY : Cytostatic. No biological data given MECHANISM OF ACTION : Modulating expression/activity of the phosphatase CDC25B, which controls entry of cells into mitosis.