BIO-DEGRADABLE COLLOID PARTICLES, IN PARTICULAR FOR PULMONARY APPLICATIONS

摘要

The invention relates to a composition consisting of a bio-degradable, water-soluble comb polymer, based on a polyol backbone with side chains that carry amino groups and a stabiliser in the form of at least one negatively charged organic base, which can be a Lewis or Brönsted base, or a corresponding acid of said base, which can be a Lewis or Brönsted acid. There can be an excess or deficiency of the acidic groups of the stabilisers in relation to the primary, secondary or tertiary amino groups of the comb polymers or an excess or deficiency of the basic groups in relation to the quaternary amino groups of the comb polymers, in such a way that the colloid particles have a positive or negative zeta potential. Colloid particles of this type are particularly suitable for the pulmonary application of acidic or negatively charged pharmaceutical active agents.