INHIBITORS OF PAPILLOMA VIRUS

摘要

The use of a compound of formula (II): or its enantiomers or diastereoisomer s thereof, or salts or pharmaceutically-acceptable esters thereof, in the treatment or prevention of a papilloma virus infection, particularly human papilloma virus in a mammal, wherein R11; X4; X5; X6; R13; R14; W; Z; Y; T; and R18 are defined herein. The present invention also provides novel compounds, pharmaceutical compositions and methods for using these compounds and compositions in the treatment or prevention of papilloma virus infection . More particularly, the present invention provides compounds, compositions an d methods for inhibiting papilloma virus DNA replication by interfering with t he E1-E2 protein-protein interaction essential for viral DNA replication.