PROCESSES FOR PRODUCING POLYMER COATINGS

摘要

A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a crosslinking agent on a medical device surface; and (b) subsequently applying a polymercontaining layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross­linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.