| 摘要 |
A solid freeform fabrication method and composition for preparing a calcium phosphate-based macro-porous scaffold for tissue engineering applications. The method includes (A) preparing a mixture of dry solid powder particles in a powder container; (B) preparing a fluid component in a reservoir separate from the powder container; wherein the powder mixture and the fluid component, separately or in combination, comprise at least a calcium source and a phosphoric acid source; (C) operating a material deposition system comprising a liquid deposition device for dispensing the fluid component from the reservoir and a solid powder-dispensing device for dispensing the solid powder mixture from the powder container to selected locations on a target surface of an object-supporting platform, wherein the dispensed fluid and dispensed powder components react to form a calcium phosphate composition (particularly hydroxyapatite or its derivative); and (D) during the operating step (C), moving the deposition system and the object-supporting platform relative to one another in X-Y-Z directions to form the scaffold containing macro pores, greater than 50 mum in size.
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