| 摘要 |
Method and formulation useful in treatment of glaucoma in a mammal wherein an effective amount of an active water soluble carbonic anhydrase inhibitor is administered, said inhibitor being a compound having the formula <IMAGE> or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of H, -OH, -CN and -OCH3; R2 is hydrogen or a lower alkyl having from one to about 5 carbon atoms; R3 is selected from the group consisting of HNHCHR4-, R5NHCHR4-, R5NHCHR4, CONHCR4-, R5NHCH2CHR4-, <IMAGE> R4 is selected from lower alkyl having from one to about 5 carbon atoms; or a naturally occurring amino acid side chain; and R5 is selected from the group consisting of H, CH3-, HCO-, CH3CO- and XCH2CO- wherein X is a halogen atom; and stereoisomers thereof.
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