发明名称 |
P53-dependent apoptosis-inducing protein and method of screening for apoptosis regulator |
摘要 |
p53-dependent Damage-Inducible Nuclear Protein 1 (p53DINP1 protein) is a p53-induced nuclear protein that induces p53-dependent apoptosis by regulating p53 function through Ser 46 phosphorylation. A DNA encoding p53DINP1 can be applied as anticancer agents for destroying neoplasms such as tumors, and as therapeutic or preventive agents for diseases associated with p53-mediated apoptosis abnormalities. It is also possible to apply the above protein and DNA in methods of screening for candidate compounds for regulating p53-mediated apoptosis.
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申请公布号 |
US2004253595(A1) |
申请公布日期 |
2004.12.16 |
申请号 |
US20040484157 |
申请日期 |
2004.07.26 |
申请人 |
NAKAMURA YUSUKE;ARAKAWA HIROFUMI |
发明人 |
NAKAMURA YUSUKE;ARAKAWA HIROFUMI |
分类号 |
G01N33/50;A61K45/00;A61P35/00;A61P43/00;C07K14/47;C07K14/82;C07K16/18;C07K16/32;C12N1/15;C12N1/19;C12N1/21;C12N15/09;C12N15/12;C12P21/02;C12Q1/02;C12Q1/48;C12Q1/68;G01N33/15;G01N33/68;(IPC1-7):C12Q1/68;G01N33/574;C07H21/04;C12N9/64 |
主分类号 |
G01N33/50 |
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