| 摘要 |
Compounds of formulae (1a) and (1b) are described: in which the dashed line represents an optional bond; A is a -N=atom or a -N(R<b>)-, -C(R<b>)= or -C(R<b>)(R<C>)- group; R<a>, R<b >and R<c >is each independently a hydrogen atom or an optionally substituted C<1-6>alkyl group; X is an -O- or -S- atom or -NH- group or substituted N atom; each Y is independently a N atom or CH group or substituted C atom; n is zero or the integer 1; Alk<1 >is an optionally substituted aliphatic or heteroaliphatic chain L<1 >is a covalent bond or a linker atom or group; Cy<1 >is a hydrogen atom or an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; Ar is an optionally substituted aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof; The compounds are potent inhibitors of p38 kinase and are use in the prophylaxis or treatment of p38 kinase mediated diseases or disorders, such as rheumatoid arthritis.
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