发明名称 POLYPEPTIDES RELATED TO NATRIURETIC PEPTIDES AND METHODS OF THEIR IDENTIFICATION AND USE
摘要 The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.
申请公布号 WO2004094459(A3) 申请公布日期 2004.12.16
申请号 WO2004US12024 申请日期 2004.04.15
申请人 BIOSITE INCORPORATED;BUECHLER, KENNETH, F. 发明人 BUECHLER, KENNETH, F.
分类号 C07K;C07K16/26;G01N33/53;G01N33/573;G01N33/68 主分类号 C07K
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