IMPROVED NOVEL, CLEAR, PAINLESS PREPARATION OF PROPOFOL

摘要

A clear, stable , ready to use anaesthetic composition comprising 2,6 Diisopropylphenol (Propofol); at least one analgesic and like drug and antioxidants in a solvent system and a process for preparing the same. The said solvent system is selected from water and 2,5 di-omethyl-1,4;3,6-dianhydro-D-glucitol and/or its derivatives in the ratio of 65:35 and cyclodextrin and its derivative and water, wherein cyclodextrin forms a complex with Propofol in a ratio of 1:1. The analgesic is selected from Lignocaine, Ketamine, Tramodol, Alfentanil, Pethidine, Ropivacaine, Bupivacaine, Ketamine and the like capable of being administered parenterally wherein ratio of Propofol: Lignocaine is 100:1 and Propofol: Ketamine is 100:5. The process for preparing the anaesthetic composition comprises mixing Propofol in solvent system for effective dissolution of Propofol followed by addition of analgesic agents and further addition of antioxidants in the desired quantity and mixing; adjusting the pH; filtering the mixture and filling in multidose vials.