发明名称 |
CELL SPECIFIC REPLICATION-COMPETENT VIRAL VECTORS COMPRISING A SELF PROCESSING PEPTIDE CLEAVAGE SITE |
摘要 |
Cell specific replication-competent viral vectors comprising a self processing peptide cleavage sequence are provided. The targeted replication-competent viral vectors include two or more co-transcribed genes under transcriptional control of the same heterologous transcriptional regulatory element (TRE), wherein at least a second gene is under translational control of a self processing cleavage sequence or 2A sequence. Exemplary vector constructs may further include an additional proteolytic cleavage site which provides a means to remove the self processing peptide sequence from the viral vector. |
申请公布号 |
WO2004108893(A2) |
申请公布日期 |
2004.12.16 |
申请号 |
WO2004US17313 |
申请日期 |
2004.06.02 |
申请人 |
CELL GENESYS, INC. |
发明人 |
KO, DEREK;LI, YUANHAO;HARDING, THOMAS;FANG, JIANMIN;RAMESH, NAGARAJAN;YU, DE CHAO |
分类号 |
A01N63/00;A61K35/76;A61K48/00;C12N;C12N5/00;C12N5/08;C12N15/00;C12N15/09;C12N15/63;C12N15/64;C12N15/66;C12N15/70;C12N15/74;C12N15/861 |
主分类号 |
A01N63/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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