摘要 |
In a first aspect, the invention provides methods for screening for modulators of a target protein, comprising the steps of contacting a target protein with a candidate agent and determining whether the candidate agent modulates the activity of the target protein, wherein the target protein comprises a sequence that has more than 80% amino acid sequence identity to KIF14 (SEQ ID NO:2) or the KIF14 motor domain (SEQ ID NO:3). In a second aspect, the invention provides methods for modulating cell proliferation comprising administering to a cell an effective amount of a modulator of the activity of a target protein. Some embodiments of this aspect provide methods for treating a subject with a cellular hyperproliferation disorder, such as cancer. In a third aspect, the invention provides methods for identifying candidate subjects for treatment with an inhibitor of the activity of a target protein. |
申请人 |
ROSETTA INPHARMATICS LLC;MERCK & CO., INC.;MAO, MAO;LINSLEY, PETER, S.;BUSER, CAROLYN, A.;MARSHALL, CHRISTOPHER, GARY;KIM, ANNETTE, S. |
发明人 |
MAO, MAO;LINSLEY, PETER, S.;BUSER, CAROLYN, A.;MARSHALL, CHRISTOPHER, GARY;KIM, ANNETTE, S. |