发明名称 |
METHODS FOR IDENTIFYING MODULATORS OF KINESIN ACTIVITY |
摘要 |
In a first aspect, the invention provides methods for screening for modulato rs of a target protein, comprising the steps of contacting a target protein wit h a candidate agent and determining whether the candidate agent modulates the activity of the target protein, wherein the target protein comprises a sequence that has more than 80% amino acid sequence identity to KIF14 (SEQ I D NO:2) or the KIF14 motor domain (SEQ ID NO:3). In a second aspect, the invention provides methods for modulating cell proliferation comprising administering to a cell an effective amount of a modulator of the activity o f a target protein. Some embodiments of this aspect provide methods for treati ng a subject with a cellular hyperproliferation disorder, such as cancer. In a third aspect, the invention provides methods for identifying candidate subjects for treatment with an inhibitor of the activity of a target protein .
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申请公布号 |
CA2527799(A1) |
申请公布日期 |
2004.12.16 |
申请号 |
CA20042527799 |
申请日期 |
2004.05.28 |
申请人 |
MERCK & CO.;ROSETTA INPHARMATICS, LLC |
发明人 |
MARSHALL, CHRISTOPHER GARY;KIM, ANNETTE S.;BUSER, CAROLYN A.;LINSLEY, PETER S.;MAO, MAO |
分类号 |
G01N33/50;A61K31/175;A61K38/00;C12Q1/34;C12Q1/48;G01N33/573;G01N33/574 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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