发明名称 |
FORMATION OF NOVEL ERYTHROPOIETIN CONJUGATES USING TRANSGLUTAMINASE |
摘要 |
The invention provides biologically active erythropoietin (EPO) conjugate compositions wherein a transglutaminase reaction is employed to covalently and site specifically conjugate the EPO molecule to a non-antigenic hydrophilic polymer that can also be covalently linked to an organic molecule either of which modification increases the circulating serum half-life of the composition. |
申请公布号 |
WO2004108667(A2) |
申请公布日期 |
2004.12.16 |
申请号 |
WO2004US16670 |
申请日期 |
2004.05.27 |
申请人 |
CENTOCOR, INC.;POOL, CHADLER T. |
发明人 |
POOL, CHADLER T. |
分类号 |
A61K38/00;A61K38/18;A61K38/52;C07D;C07K1/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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