发明名称 |
NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES |
摘要 |
There is disclosed the use of a compound of formula (I) wherein R<SUP>1</SUP>, R<SUP>2</SUP>, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease. |
申请公布号 |
EP1263711(B1) |
申请公布日期 |
2004.12.15 |
申请号 |
EP20010906492 |
申请日期 |
2001.02.20 |
申请人 |
ASTRAZENECA AB |
发明人 |
CHESHIRE, DAVID;CONNOLLY, STEPHEN;COX, DAVID;HAMLEY, PETER;METE, ANTONIO;PIMM, AUSTEN |
分类号 |
C07D295/08;A61K31/137;A61K31/138;A61K31/275;A61K31/277;A61K31/341;A61K31/381;A61K31/40;A61K31/4164;A61K31/42;A61K31/421;A61K31/426;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4412;A61K31/445;A61K31/4453;A61K31/4462;A61K31/495;A61K31/4965;A61K31/505;A61K31/5375;A61K45/00;A61P1/00;A61P19/02;A61P25/04;A61P29/00;A61P43/00;C07C209/68;C07C217/48;C07C253/30;C07C255/54;C07D207/12;C07D211/22;C07D211/46;C07D213/38;C07D213/50;C07D213/61;C07D213/64;C07D233/24;C07D233/64;C07D239/26;C07D241/12;C07D261/08;C07D263/32;C07D277/28;C07D295/092;C07D307/14;C07D307/52;C07D333/20 |
主分类号 |
C07D295/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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