ANTI-ALPHAVBETA3 HUMANIZED MONOCLONAL ANTIBODIES

摘要

An altered antibody which is specifically reactive with the human alpha vbeta 3 protein receptor and capable of neutralising the receptor, comprising a heavy chain comprising at least one complementarity determining region (CDR) sequence of the 117aa (encoded by the 351 bp sequence given in the specification), and functional fragments of the antibody. Also claimed are: (1) an isolated nucleic acid molecule selected from: (a) a nucleic acid sequence encoding any of the antibodies and fragments as above; (b) a nucleic acid complementary to any of the sequences in (a); and (c) a nucleic acid sequence of 18 or more nucleotides capable of hybridising to (a) or (b) under stringent conditions; (2) a recombinant plasmid comprising the nucleic acid sequence as in (1); (3) a host cell comprising a plasmid as in (2); (4) a murine monoclonal antibody (MAb) and functional fragments, specifically reactive with the human alpha vbeta 3 receptor and capable of neutralising the receptor, having a heavy chain comprising at least one CDR sequence of another 117aa (encoded by another 351 bp sequence given in the specification).