| 发明名称 |
Method for generating and identifying antibodies directed against a B7 |
| 摘要 |
The invention provides a method for generating and identifying antibodies directed against a B7 antigen having SEQ ID NO. 8 or a fragment of SEQ ID NO. 8, which antibodies inhibit B cells from binding CD28, comprising immunizing an animal with the B7 antigen so as to produce the antibodies; and screening the antibodies for antibodies that bind B7 and inhibit CD28 binding to B cells.
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| 申请公布号 |
US6830937(B1) |
申请公布日期 |
2004.12.14 |
| 申请号 |
US20000666267 |
申请日期 |
2000.09.21 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
LINSLEY PETER S.;LEDBETTER JEFFREY A.;DAMLE NITIN K.;BRADY WILLIAM |
| 分类号 |
A61K38/00;C07K14/705;C07K16/28;G01N33/569;(IPC1-7):G01N33/53 |
主分类号 |
A61K38/00 |
| 代理机构 |
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