发明名称 |
Nucleic acid molecule, method and kit for selecting a nucleic acid having a desired feature |
摘要 |
This invention relates to the screening of nucleic acids. More particularly, the present invention provides a dysfunctional viral genome capable of both expressing libraries of exogenous nucleic acids and selecting the sequences having a predefined characteristic or function within the cell, such as nucleic acids encoding signal peptides, secreted proteins, membrane bound proteins, proteases and drug-resistance proteins. The invention further provides a method and a kit for selecting nucleic acids having a desired feature, wherein production of a viral particle is dependent on insertion of an exogenous nucleic acid having the desired feature into a dysfunctional viral genome or into a viral genome exposed to a substance inhibiting viral packaging function(s).
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申请公布号 |
US6830885(B1) |
申请公布日期 |
2004.12.14 |
申请号 |
US20000641931 |
申请日期 |
2000.08.18 |
申请人 |
PHENOGENE THERAPEUTIQUES INC. |
发明人 |
LANCTOT CHRISTIAN;MOFFAT PIERRE;SALOIS PATRICK |
分类号 |
C12N15/10;C12N15/86;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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