ANTI-MICROBIAL COMPOSITION COMPRISING PINOSYLVIN AND PROCESS FOR SYNTHESIZING PINOSYLVIN

摘要

PURPOSE: Provided are an anti-microbial composition useful for living goods and food preservatives requiring both physiological and bactericidal action, and a process for synthesizing pinosylvin in large quantities. CONSTITUTION: The anti-microbial composition comprises pinosylvin of the formula I as an effective ingredient. The pinosylvin is synthesized from pine needles by the process comprising the steps of: subjecting a mixture of benzylbromide and triethyl phosphite to TLC and distillation to obtain diethylbenzyl phosphite; adding 3,5-dimethoxybenzyl aldehyde to a mixture of the obtained diethylbenzyl phosphite, dimethyl formamide and sodium methoxide which are cooled under nitrogen gas; subjecting the mixture to TLC and addition of a mixture of water and methanol to precipitate the reaction product; purifying a filtrate by chromatography to obtain 3,5-dimethoxystilbene; extracting a mixture of 3,5-dimethoxystilbene and pyridine hydrochloride using HCl and ether solution; removing water and solvent from ether layer; and purifying the product by column chromatography.