OLIGONUCLEIC ACID-BEARING COMPOSITE AND PHARMACEUTICAL COMPOSITION CONTAINING THE COMPOSITE

摘要

A composite comprising as a main ingredient a cationic ribosome composed of 2-O-(2-diethylaminoethyl)carbamoyl-1,3-O-dioleoylglycerol and phospholipid, the cationic ribosome bearing an oligonucleic acid. This composite can be administered in a living body and exerts medicinal effect therein, so that it can find practical use in pharmaceuticals. Thus, there is provided a preventive or therapeutic drug composition for diseases in which target molecules of the oligonucleic acid (target DNA, target RNA and target protein) take part, which drug composition comprises the above composite.