| 摘要 |
Compounds having he general structure I are provided. X and Y are independently selected from the group consisting of CH2, N, NR<9>, C=O, C=S, S=O, SO2, S, O, (CR<6>R<7>)n, C(=O)-(CR<6>R<7>)n, and C(=S)-(CR<6>R<7>)n, where n is 1, 2, or 3. W is selected from the group consisting of (formula I) and L is selected from the group consisting of N, O, S=O, SO, C(O), NC(O), NC(S), OC(O), OC(S), C(NR<10>), C(NOR<10>), and a covalent bond. Z<1>, Z<2>, and Z<3 >are independently selected from the group consisting of substituted carbon and nitrogen. Compounds of formula I are agonists of the melanocortin-4 receptor (''MC-4r2) and therefore may have useful properties for controlling diseases related to MC-4r action in humans, such as obesity and type II diabetes.
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