MOLECULES AND ANALOGUES OF THE AGELASTATIN FAMILY OF ANTITUMOUR AND GSK-3beta-INHIBITING ALKALOIDS

摘要

A compound of general structure (I); or, a pharmaceutically acceptable salt thereof, wherein, C---A and Z---C = independently a single or a double bond; A = C, N, O, S, or Se; Z = C, N, 0, S, or Se; R<1>, R<2>, R<3>, R<7> and R<8> are independently selected from H, CI-10 alkyl, Cl-10 cycloalkyl, aryl, substituted aryl, optionally substituted alkylaryl, halogen, haloalkyl, OR<9>, SR<9>, OH, N02 CN, NH2, NHR<9>, N(R<9>)2, NHOR<9>, NHCONHR<9>, NHCONR<9>2, NR<9>COR<9>, NHC02R<9>, C02R<9>, C02H, COR<9>, CONHR<9>, CON(R<9>)2, S(O)2R<9>, S(O)R<9>, SONH2 SO2NHR<9>, NHS(O)2R<9>, and Si(R<9>)3 groups, or an optionally substituted heterocyclic group; and R<9> = H, Cl-10 alkyl, Cl-10 cycloalkyl, aryl, substituted aryl, optionally substituted alkylaryl.