TRISUBSTITUTED HETEROAROMATIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS

摘要

Trisubstituted heteroaromatic compounds having the structure Formula (I) are provided, wherein X is C or N; A and B are each independently CH or N, with the proviso that A and B cannot both be CH; R<1> is Ar-L-; R<2> is hydrogen or alkyl; or R<1> and R<2> can be joined together to form a 4- to 7-membered cycloheteroalkyl ring; R<3> to R<8>, Ar and L are as defined herein. A method for using these compounds to treat diseases associated with abnormal bone or mineral homeostasis is also provided.