| 发明名称 |
Fluorinated trienes and their use as rxr modulators |
| 摘要 |
The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula 1: The compounds of Structural Formual 1 are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis.
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| 申请公布号 |
US2004248919(A1) |
申请公布日期 |
2004.12.09 |
| 申请号 |
US20040471383 |
申请日期 |
2004.04.15 |
| 申请人 |
BELL MICHAEL GREGORY;GRESE TIMOTHY ALAN;GERNETT DOUGLAS LINN;YUMIBE NATHAN P.;BOEHM MARCUS F.;MICHELLYS PIERRE-YVES;ARDECKY ROBERT J.;MAPES CHRISTOPHER M;CHEN JYUN-HUNG;TYHONAS JOHN S.;HAMANN LAWRENCE G. |
发明人 |
BELL MICHAEL GREGORY;GRESE TIMOTHY ALAN;GERNETT DOUGLAS LINN;YUMIBE NATHAN P.;BOEHM MARCUS F.;MICHELLYS PIERRE-YVES;ARDECKY ROBERT J.;MAPES CHRISTOPHER M;CHEN JYUN-HUNG;TYHONAS JOHN S.;HAMANN LAWRENCE G. |
| 分类号 |
A61P3/04;A61K31/192;A61P3/00;A61P3/10;A61P9/00;A61P9/10;A61P17/00;A61P17/02;A61P17/06;A61P17/10;A61P17/14;A61P25/00;A61P29/00;A61P35/00;A61P43/00;C07B61/00;C07C51/09;C07C59/64;C07C67/343;C07C69/734;(IPC1-7):C07C69/76;A61K31/40;A61K31/19;C07D207/46 |
主分类号 |
A61P3/04 |
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