发明名称 |
Ophthalmic composition containing n-acetylcysteine for the treatment of dry-eye syndrome |
摘要 |
An ophthalmic pharmaceutical composition containing acetylcysteine as the active ingredient having a mucolitic action, suitable for administration in eyedrops, where N-acetyl-cysteine is neutralised with base DEAE-dextrane in order to reach pH levels preferably between 6.0 and 7.5, and having a physiologically acceptable osmolarity less than 320 mOsm/kg. The presence of a neutralising agent for N-acetyl-cysteine that does not negatively affect the composition osmolarity allows the formulation to be isotonic or even hypotonic, thus avoiding the irritative and potentially damaging effects of previous ophthalmic products containing N-acetyl-cysteine.
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申请公布号 |
US2004248847(A1) |
申请公布日期 |
2004.12.09 |
申请号 |
US20040484241 |
申请日期 |
2004.06.30 |
申请人 |
BOLDRINI ENRICO;SAETTONE MARCO FABRIZIO;CHETONI PATRIZIA;BURGALASSI SUSI;GIANACCINI BORIS |
发明人 |
BOLDRINI ENRICO;SAETTONE MARCO FABRIZIO;CHETONI PATRIZIA;BURGALASSI SUSI;GIANACCINI BORIS |
分类号 |
A61K9/00;A61K31/195;A61K47/36;A61P27/04;(IPC1-7):A61K31/198 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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地址 |
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