KINETIC ISOLATION PRESSURIZATION

摘要

A method of delivering a therapeutic agent to a targeted location within a patient efficiently delivers the agent with a reduced systemic effect. The method includes providing a non-perforated delivery device (10) having at least one wall (12) through which a fluid at first fluid pressure can pass through. The non-perforated delivery device (10) is positioned to provide a radial fluid force against the targeted location. The fluid, including at least one therapeutic agent, is supplied to the therapeutic agent delivery device (10) at the first fluid pressure. The fluid passes through the at lea st one wall (12) of the delivery device (10) to create a semi-confined space external to the delivery device (10) at a second fluid pressure. The deliver y device (10) applies the radial fluid force against the semi-confined space a nd the fluid disposed therein while simultaneously facilitating the fluid passi ng through the delivery device (10) to maintain the second fluid pressure in th e semi-confined space at the targeted location. The fluid contains at least on e therapeutic agent that is distributed to the targeted location in a substantially uniform distribution in an amount sufficient to create a therapeutic effect modulatable by the fluid pressure and a dwell time.