Crystals and structures of epidermal growth factor receptor kinase domain

摘要

The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of EGFRKD complexed with AMP-PNP and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of EGFRKD, and compounds and compositions that affect EGFR activity.