COMPOSITION COMPRISING EXTRACT OF ASTILBE RUBRA OR ASTILBIC ACID AND PELTOBOYKINOLIC ACID DERIVATIVES WHICH HAS ANTI-INFLAMMATORY OR ANTI-ALLERGIC ACTIVITIES BY INHIBITING LYSOPAF-ACETYLTRANSFERASE AND 5-LIPOXYGENASE

摘要

PURPOSE: Provided is a composition having anti-inflammatory or anti-allergic activity which comprises the extract of Astilbe rubra or astilbic acid and peltoboykinolic acid derivatives. Therefore, the composition inhibits the activity of lysoPAF-acetyltransferase which synthesizes PAF, and 5-lipoxygenase which synthesizes eicosanoid. CONSTITUTION: The pharmaceutical composition for preventing and treating inflammatory and atopic diseases is characterized by containing 0.01-50% of: the crude extract of Astilbe rubra using methanol or the nonpolar solvent soluble extrct of Astilbe rubra using hexan, as active ingredients; or astilbic acid and peltoboykinolic acid derivatives or their pharmaceutically acceptable salts.