发明名称 |
A NUCLEIC ACID CONSTRUCT ENCODING A PROCESSING COMPONENT DERIVED FROM THE N-TERMINAL REGION OF THE HEPATITIS VIRUS ORF2, AND AN ANTIGENIC POLYPEPTIDE |
摘要 |
A method for enhancing an immune response to a nucleic acid vaccine comprising administering to an animal a nucleic acid construct encoding a fusion protein comprising a processing component and an antigenic polypeptide of interest wherein said processing component provides heterogeneous processing of the antigenic polypeptide when the nucleic acid construct is expressed in a host cell and a resulting enhancement of the immune response. The processing component is derived from an N-terminal portion of PORF2 of Hepatitis E virus. |
申请公布号 |
EP1274851(A4) |
申请公布日期 |
2004.12.08 |
申请号 |
EP20010916744 |
申请日期 |
2001.03.30 |
申请人 |
MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LIMITED |
发明人 |
LI, FAN;ANDERSON, DAVID, ANDREW;PURCELL, DAMIAN, FRANCIS, JOHN |
分类号 |
C12N15/09;A61K31/7088;A61K39/00;A61K39/29;A61K39/39;A61P31/04;A61P31/12;A61P35/00;A61P37/06;C07K14/02;C07K14/08;C12N5/10;(IPC1-7):C12N15/62;A61K31/713 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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