PROCESS FOR PRODUCING OPTICALLY ACTIVE SULFOXIDE DERIVATIVE

摘要

A process for preparing an optically active sulfoxide derivative (I) having CCR5 antagonism without causing side reactions such as racemization and Pummerer rearrangement, which comprises reacting a compound (II) with a compound (III) as shown by the following scheme: wherein R<1> represents hydrogen, an aliphatic hydrocarbon group or an aromatic group; R<2> represents halogeno, alkyl, hydroxyl, amino, an aromatic group, etc.; R<3> represents a 5- or 6-membered ring; R<4> represents hydrogen, alkyl, alkoxy or halogeno; R<5> represents hydrogen, a hydrocarbon group, a heterocyclic group, acyl, etc.; ring A represents an optionally substituted benzene ring; X represents a bond or divalent group comprising a linear part constituted of 1 to 4 atoms; m represents an integer of 1 to 5; n represents an integer of 0 to 3; p represents an integer of 0 to 2; and <*1> represents an asymmetric center.