发明名称 |
CONTROLLED MODULATION OF AMINO ACID SIDE CHAIN LENGTH OF PEPTIDE ANTIGENS |
摘要 |
<p>The invention provides a method for the creation of peptide antigens comprising epitopes with at least a first modification comprising a shortened or lengthened amino acid side chain. By extension or shortening of the side chain with CH3/CH2 groups, for example, made by computer assisted modeling of the tumor antigen (peptide) bound in the MHC-I-groove, immunogenicity can be improved with minimal modification of adjacent tertiary structure, thereby avoiding cross-reactivity. Provided by the invention are methods of creating such antigens, as well as methods for therapeutic or prophylactic treatment of various conditions comprising administration of the antigens.</p> |
申请公布号 |
EP1482963(A2) |
申请公布日期 |
2004.12.08 |
申请号 |
EP20030723688 |
申请日期 |
2003.03.06 |
申请人 |
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
IOANNIDES, CONSTANTIN, G.;CAMPBELL, MARTIN, L.;O'BRIAN, CATHERINE, A. |
分类号 |
A61K38/04;A61K39/00;A61K39/02;A61K39/12;C07K14/47;C12N;G01N33/53;(IPC1-7):A61K38/04 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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