发明名称 |
Adjustable threshold switch |
摘要 |
Provided are methods and compositions for regulating gene expression in a cell. The invention provides recombinant adjustable-threshold switches which contain a first inducible promoter-regulatory gene operon and a second constitutive promoter-regulatory gene operon. A threshold amount of activating agent is required to switch the inducible promoter "on" and the constitutive promoter "off". An adjustable-threshold switch is useful to reversibly switch the expression of a gene of interest between a stable "on" state and stable "off" state in response to an activating agent at or above a threshold concentration.
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申请公布号 |
US6828140(B2) |
申请公布日期 |
2004.12.07 |
申请号 |
US20010872339 |
申请日期 |
2001.06.01 |
申请人 |
CELLICON TECHNOLOGIES, INC. |
发明人 |
GARDNER TIMOTHY;COLLINS JAMES J. |
分类号 |
C12N1/11;C12N1/19;C12N15/63;(IPC1-7):C12N1/20;C12N15/00;C12N15/09;C12N15/86;C07H21/04 |
主分类号 |
C12N1/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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