发明名称 |
Nicotine-containing, controlled release composition and method |
摘要 |
A nicotine product having a nicotine release rate of not less than 70% over a 10 minute period as well as a process to produce such product. Such product is produced by a process comprising the steps of(a) preparing an aqueous solution of an organic polyol;(b) mixing said aqueous solution of the organic polyol with a cation exchange resin selected from the group consisting of (i)-a methacrylic, weakly acidic type of resin containing carboxylic functional groups (ii)-polystyrene, strongly acidic type of resin containing sulfonic functional groups and (iii)-polystyrene, intermediate acidic type of resin containing phosphonic functional groups thereby forming a cation exchange resin mixture having some of its ion exchange sites partially blocked with said polyol;(c) admixing with said mixture of step (b) an aqueous solution of nicotine to form a nicotine-coated cation exchange resin admixture; and(d) removing water from said admixture.The nicotine composition having a nicotine release rate of not less than 70% over a 10 minute period results.
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申请公布号 |
US6828336(B2) |
申请公布日期 |
2004.12.07 |
申请号 |
US20030429420 |
申请日期 |
2003.05.05 |
申请人 |
CAMBREX CHARLES CITY, INC. |
发明人 |
WALLING JOHN A. |
分类号 |
A61K9/22;A61K31/465;(IPC1-7):A61K31/465;C07D401/04 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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