发明名称 |
Methods for administration of paclitaxel |
摘要 |
Methods are provided for using paclitaxel for treating diseases associated with abnormal cell proliferation and angiogenesis. In particular, methods are provided for administration of paclitaxel formulated with vitamin E derivatives such as d-alpha-tocopherol polyethylene glycol succinate to a cancer patient. By administering to a patient paclitaxel in a vehicle containing a solubilizer other than Cremophor, acute hypersensitivity caused by Cremophor can be avoided and therapeutic index of paclitaxel may also be increased through potentiation of anti-neoplastic effects by the vitamin E derivatives.
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申请公布号 |
US6828346(B2) |
申请公布日期 |
2004.12.07 |
申请号 |
US20030351262 |
申请日期 |
2003.01.23 |
申请人 |
SUPERGEN, INC. |
发明人 |
JOSHI-HANGAL RAJASHREE;SANDS HOWARD;RUBINFELD JOSEPH |
分类号 |
A61K9/107;A61K9/48;A61K31/337;A61K47/48;(IPC1-7):A61K31/335;A61K31/56;A61K31/34;A61K31/135 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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