发明名称 |
ANTIBODIES ABOLISH PRION PROPAGATION AND PROMOTE CLEARANCE OF INFECTIVITY. |
摘要 |
<p>Methods are disclosed whereby formulations of molecules are administered rendering cells resistant to infection with infectious proteins such as prions. The formulation preferably comprises a plurality of Fab fragments which (1) recognize and selectively bind to a range of epitopes on the protein of interest, (e.g. epitopes on PrPC) and (2) bind to epitopes which interrupt the chain of events resulting in a change of the protein's conformation to an infectious disease conformation of the protein. The molecules and formulation are also useful in clearing infectious proteins from cells.</p> |
申请公布号 |
MXPA03010051(A) |
申请公布日期 |
2004.12.06 |
申请号 |
MX2003PA10051 |
申请日期 |
2002.04.25 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DAVID PERETZ |
分类号 |
G01N33/53;A61K39/395;A61P31/00;C07K16/18;C12N5/06;C12N5/28;C12P21/08;(IPC1-7):A61N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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