FRAGMENT OF FAF-1 WHICH HAS INHIBITORY EFFECTS ON ANGIOGENESIS AND CELL PROLIFERATION AND TUMOR METASTASIS INHIBITORY AGENT CONTAINING THE SAME

摘要

PURPOSE: Provided is a fragment of FAF-1(Fas-associated Factor 1) which has excellent inhibitory effects on angiogenesis and cell proliferation without cytotoxicity. Therefore, it is useful for an anticancer agent, especially, a tumor metastasis inhibitory agent. CONSTITUTION: The fraction having inhibitory effect on tumor metastasis is characteristically composed of 290-345 amino acids of FAF1(Fas-associated Factor 1). Its amino acid sequence is represented by the SEQ ID NO:1. Its coding DNA is represented by the SEQ IN NO:2. The anticancer agent is characterized by containing the fraction of FAF1.