| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for examining and modulating mitochondria permeability and apoptosis, and to obtain a reagent. SOLUTION: A compound selected from the group consisting of a compound of formula I and a compound of formula II is used as a modulator and an affinity label of an MPTP complex. Further, the method for modulating the activity of the MPTP complex, a method for determining the presence of the components of the MPTP complex, and a method for identifying an active agent for modulating the activity of the MPTP complex are provided. Concretely, the method for identifying the active agent for modulating the activity of the MPTP complex by interacting with a VDAC1 component is also provided. COPYRIGHT: (C)2005,JPO&NCIPI |
