发明名称 |
METHODS OF REDUCING VASCULAR PERMEABILITY IN TISSUE BY INHIBITION OF TISSUE PLASMINOGEN ACTIVATOR (TPA) AND TPA INHIBITORS USEFUL THEREIN |
摘要 |
The present invention is a method of reducing vascular permeability in tissue of a subject comprising inhibiting the activity of serine proteinase tissue-type plasminogen activator (tPA). This tPA activity which increases permeability of the tissue in a subject results in edema in the tissue is separate from tPA's thrombolytic activity. The present invention more specifically relates to administering an amount of a tPA inhibitor sufficient to reduce the vascular permeability increasing activity of tPA in a subject. Useful tPA inhibitors for the present method are neuroserpin, mutant neuroserpin, wild-type PAI- 1, mutant PAI- 1, an antibody that binds to tPA, an antibody that binds to the low-density lipoprotein (LDL) receptor or a low-density lipoprotein (LDL) receptor family antagonist. |
申请公布号 |
WO2004103313(A2) |
申请公布日期 |
2004.12.02 |
申请号 |
WO2004US15873 |
申请日期 |
2004.05.20 |
申请人 |
THE AMERICAN NATIONAL RED CROSS;LAWRENCE, DANIEL, A.;YEPES, MANUEL, S.;STRICKLAND, DUDLEY |
发明人 |
LAWRENCE, DANIEL, A.;YEPES, MANUEL, S.;STRICKLAND, DUDLEY |
分类号 |
A61K;A61K39/395;G01N33/50;G01N33/53 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|