COMPOSITIONS COMPRISING PATHOGEN ELICITED EPITHELIAL CHEMOATTRACTANT (EICOSANOID HEPOXILIN A3), INHIBITORS THEREOF AND METHODS OF USE THEREOF

摘要

The present invention relates to the use of eiconosoid hepoxilin A3 to modulate epithelial transmigration of inflammatory cells. The present invention further relates to pharmaceutical compositions comprising native hepoxilin A3, hepoxilin A3 analogs, or specific inhibitors thereof, as well as inhibitors of the biosynthetic pathway of hepoxilin A3. Compositions and methods of the present invention are useful for enhancing cellular immunity or treating disorders associated with epithelial inflammation.