摘要 |
A polymer type antitumor agent comprising a polymer micelle complex structure formed as a result of intermolecular boding or interaction between a low-molecular antitumor agent, such as an anthracycline antitumor agent (e.g., pirarubicin, doxorubicin, epirubicin, daunorubicin or aclarubicin), cisplatin or an alkaloid antitumor agent (e.g., taxol), and a styrene/maleic acid copolymer (SMA). This polymer type antitumor agent exerts excellent effects, namely, enhancing the selective accumulation of drug on tumor region so as to increase an antitumor efficacy while avoiding the accumulation on normal organs and tissues so as to reduce side effects thereof. This polymer type antitumor agent can be obtained through a process comprising dissolving SMA and an antitumor agent in a water base solvent, effecting a pH adjustment in the presence of soluble carbodiimide, amino acid or polyamine so as to form a micelle complex structure and separating and recovering the polymer component. |