| 摘要 |
This invention relates to a diamine derivative represented by the following formula (1) or a salt thereof. <CHEM> wherein R<1> represents H, OH, an aralkyloxy group or a halogen atom; R<2> represents H or a lower alkyl group; A represents -C(R<3>)=CH-, -CH=N-, -N(R<4>)-, R<3> being H or OH, R<4> being a lower alkyl group or an alkoxyalkyl group, -O-, or -S-; B represents a single bond, -C(R<5>)(R<6>)-(CH2)k-, R<5> and R<6> being H or a lower alkyl group, and k being a value of from 0 to 2, -S(O)qCH(R<7>), or -CH=CH-; E represents a single bond or -(CH2)3-; W and Y individually represent -CH2- or -CO-; Z represents O or S; and m is a value of 2 or 3, and n is a value of from 1 to 4; with the proviso that E is -(CH2)3- when B is a single bond and E is a single bond when B is a group other than a single bond. The diamine derivatives or salts thereof have both antileukotrienic action and antihistaminic action and are low in brain penetration, and are hence useful as asthma preventives and curatives. |
