发明名称 |
Semi-synthetic saponin analogs with carrier and immune stimulatory activities for DNA and RNA vaccines |
摘要 |
The present invention discloses novel saponin derivatives for use with nucleic acids that induce an immune response when administered to animals and humans. The novel saponin derivatives disclosed comprise (a) a saponin aglycone core, wherein the aglycone core is covalently linked to one or more oligosaccharide chains; (b) a positively charged cationic chain, and optionally (c) a naturally occurring or synthetic lipophilic chain. Pharmaceutical and veterinary compositions comprising one or more of the novel saponin derivatives and saponin derivative/polynucleotide complexes are also disclosed. Disclosed as well are methods of using the novel saponin derivatives to deliver a polynucleotide molecule to cells of an animal, to stimulate or generate an immune response in an animal, and to generate a detectable immune response in an animal.
|
申请公布号 |
US2004242502(A1) |
申请公布日期 |
2004.12.02 |
申请号 |
US20040820036 |
申请日期 |
2004.04.08 |
申请人 |
GALENICA PHARMACEUTICALS, INC. |
发明人 |
MARCIANI DANTE J. |
分类号 |
A61K31/70;A61K31/704;C07G3/00;C07G11/00;C07H15/24;C07J17/00;C12N;(IPC1-7):A61K31/704 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|