THERAPEUTICAL USE OF ANTI-CD70 ANTIBODY FOR TREATING OR PREVENTING AIDS

摘要

The invertion relates to the therapeutical use of an anti-CD70 antibody for preventing a decrease in the number of T cells i.e. for the treatment or preventing Aids (characterised by T cell immunodeficiency). It is shown that chronic stimulation of murine T cells via CD70 induced excessive effector/memory T cell formation in a CD27- and antigen-dependent but IFN-g-independent manner. At the same time the naive T cell population is progressively depleted from the lymph nodes, which undermines the integrity of the immune system and ultimately leads to host death through opportunistic infection.