DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH DIPEPTIDYLPEPTIDASE IV (DPP4)

摘要

The invention provides a human DPP4 which is associated with the cardiovascular disorders, dermatological disorders, cancer disorders, hematological disorders, respiratory diseases, gastrointestinal and liver diseases, urological disorders and metabolic diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, cancer disorders, hematological disorders, respiratory diseases, gastrointestinal and liver diseases, urological disorders and metabolic diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP4 as well as pharmaceutical compositions comprising such compounds.